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Association of accelerometer-measured rest-activity rhythm patterns and parameters with cardiovascular and all-cause mortality in older adults

Chen S, Su Q, Shen R, Zhang H, Lin X, Yu S +2 more
Experimental Gerontology 20262026CC BY-NC-ND 4.0
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Published articlePublication date: Mar 2026Added to atlas: Oct 15, 2026Source
Citations3Crossref referencesChecked Oct 16, 2026
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Activity counts measure attention, not model quality. Missing counts are unknown. Publication status follows the linked source; a listed venue alone does not confirm peer review.

NHANES 2011–2014 wrist accelerometry, 1,710 adults ≥60 y, median 6.67 y follow-up. GMM found 4 RAR patterns (morning-, earlier-, delayed-, evening-type); evening-type vs morning-type CVD mortality HR 12.16 (4.02–36.82), all-cause 3.31 (1.91–5.72); higher IS and RA protective.

  • Signals: Accelerometer
  • Result: Cox models were used to compare the hazard ratio (HR) and 95% confidence interval (CI) of mortality among participants with different RAR parameters and patterns.
  • Result: Compared to 'morning-type', 'evening-type' was associated with higher risks of cardiovascular (HR: 12.16, 95% CI: 4.02-36.82) and all-cause mortality (HR: 3.31, 95% CI: 1.91-5.72).
At a glance
Venue
Experimental Gerontology 2026
Published
2026
DOI
10.1016/j.exger.2026.113043 (opens in a new tab)
arXiv
Not reported
PMID
41581839 (opens in a new tab)
Licence
CC BY-NC-ND 4.0 (opens in a new tab)
Signals
Not reported
Form factor
Not reported
Devices
Datasets
Subjects
1710 participants
Code
Not reported
Added
Oct 15, 2026

Abstract

BackgroundRest-activity rhythm (RAR) is a fundamental biomarker of age-related circadian system deterioration. However, the long-term effect of RAR patterns on mortality in older adults remains unclear.MethodsThis study analysed data from National Health and Nutrition Examination Survey 2011-2014. The RAR parameters were derived from wrist accelerometers, and four patterns were identified through clustering analysis using Gaussian mixture models. Cox models were used to compare the hazard ratio (HR) and 95% confidence interval (CI) of mortality among participants with different RAR parameters and patterns.ResultsThis study included 1710 participants aged ≥60 years. The median follow-up duration was 6.67 years. In total, 269 all-cause deaths and 77 cardiovascular deaths occurred during follow-up period. Four RAR patterns were identified: 'morning-type', 'earlier-type', 'delayed-type', and 'evening-type'. Compared to 'morning-type', 'evening-type' was associated with higher risks of cardiovascular (HR: 12.16, 95% CI: 4.02-36.82) and all-cause mortality (HR: 3.31, 95% CI: 1.91-5.72). Higher interdaily stability was associated with lower risks of cardiovascular (HR: 0.67, 95% CI: 0.55-0.81), and all-cause mortality (HR: 0.86, 95% CI: 0.74-1.00). Higher relative amplitude was associated with lower risks of cardiovascular (HR: 0.61, 95% CI: 0.49-0.75), and all-cause mortality (HR: 0.70, 95% CI: 0.60-0.81). Conversely, higher intradaily variability was associated with increased risk of cardiovascular (HR: 1.30, 95% CI: 1.15-1.46) and all-cause mortality (HR: 1.19, 95% CI: 1.10-1.30).ConclusionsRAR patterns and parameters were significantly associated with cardiovascular and all-cause mortality in older adults. Early identification and intervention for adverse RAR patterns may help improve long-term health outcomes.

Verbatim fromEurope PMC· Licence: cc by-nc-nd

Association of accelerometer-measured rest-activity rhythm patterns and parameters with cardiovascular and all-cause mortality in older adults: ChatPPG research summary card

How it works

How Method works: Setup → Method → ResultSetup: Cohort (1710 participants); Signals (Accelerometer). Method: Method. Result: Result (Cox models were used to compare the hazard ratio (HR) and 95% confidence interval (CI) of mortality among participants with different RAR parameters and patterns.); Result (Compared to 'morning-type', 'evening-type' was associated with higher risks of cardiovascular (HR: 12.16, 95% CI: 4.02-36.82) and all-cause mortality (HR: 3.31, 95% CI: 1.91-5.72).).SetupCohort: 1710 participantsCohort1710 participantsSignals: AccelerometerxyzSignalsAccelerometerMethodMethodResultResult: Cox models were used to compare the hazard ratio (HR) and 95% confidence interval (CI) of mortality among participants with different RAR parameters and patterns.ResultCox models were used to compare the…Result: Compared to 'morning-type', 'evening-type' was associated with higher risks of cardiovascular (HR: 12.16, 95% CI: 4.02-36.82) and all-cause mortality (HR: 3.31, 95% CI: 1.91-5.72).ResultCompared to 'morning-type'…
Cohort
1710 participants

Devices· 1

ActiGraph GT3X+
ActiGraph · Wrist
IMU

Illustrations by form factor; product photos are added as licences clear.

Datasets used· 1

Dataset
NHANES 2011-2012 Physical Activity Monitor - Raw Data 80hz (PAX80_G)
cdc-nchs
IMU

Cite

@article{chenrargmmpatternsmortal2026,
  title = {{Association of accelerometer-measured rest-activity rhythm patterns and parameters with cardiovascular and all-cause mortality in older adults}},
  author = {Chen S and Su Q and Shen R and Zhang H and Lin X and Yu S and Chen M and et al.},
  year = {2026},
  journal = {Experimental Gerontology 2026},
  doi = {10.1016/j.exger.2026.113043}
}

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