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Bright light therapy: improved sensitivity to its effects on rest-activity rhythms in Alzheimer patients by application of nonparametric methods

Van Someren EJ, Swaab DF, Colenda CC, Cohen W, McCall WV, Rosenquist PB
Chronobiology International 19991999
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Published articlePublication date: Jan 1999Added to atlas: Oct 15, 2026Source
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Activity counts measure attention, not model quality. Missing counts are unknown. Publication status follows the linked source; a listed venue alone does not confirm peer review.

It was demonstrated that the light-induced improvement in coupling of the rest-activity rhythm to the environmental zeitgeber of bright light is better detected using nonparametric procedures. Guidelines for analyses of actigraphic data are given to improve the sensitivity to treatment effects in future studies.

  • Venue: Chronobiology International 1999
At a glance
Venue
Chronobiology International 1999
Published
1999
DOI
10.3109/07420529908998724 (opens in a new tab)
arXiv
Not reported
PMID
10442243 (opens in a new tab)
Licence
Not reported
Signals
Not reported
Form factor
Not reported
Subjects
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Code
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Added
Oct 15, 2026

Abstract

Sleep-wake rhythm disturbances in patients with Alzheimer's disease (AD) make a strong demand on caregivers and are among the most important reasons for institutionalization. Several previous studies reported that the disturbances improve with increased environmental light, which, through the retinohypothalamic tract, activates the suprachiasmatic nucleus (SCN), the biological clock of the brain. The data of recently published positive and negative reports on the effect of bright light on actigraphically assessed rest-activity rhythms in demented elderly were reanalyzed using several statistical procedures. It was demonstrated that the light-induced improvement in coupling of the rest-activity rhythm to the environmental zeitgeber of bright light is better detected using nonparametric procedures. Cosinor, complex demodulation, and Lomb-Scargle periodogram-derived variables are much less sensitive to this effect because of the highly nonsinusoidal waveform of the rest-activity rhythm. Guidelines for analyses of actigraphic data are given to improve the sensitivity to treatment effects in future studies.

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Bright light therapy: improved sensitivity to its effects on rest-activity rhythms in Alzheimer patients by application of nonparametric methods: ChatPPG research summary card

Cite

@article{vansomerennonparametricr1999,
  title = {{Bright light therapy: improved sensitivity to its effects on rest-activity rhythms in Alzheimer patients by application of nonparametric methods}},
  author = {Van Someren EJ and Swaab DF and Colenda CC and Cohen W and McCall WV and Rosenquist PB},
  year = {1999},
  journal = {Chronobiology International 1999},
  doi = {10.3109/07420529908998724}
}

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