Paperdoi:10.64898/2026.04.20.719559
Spectral emission profile and wavelength tolerances affect pulse oximeter performance
bioRxiv preprint (not peer reviewed)
TL;DR
Monte Carlo photon-transport simulation of reflective pulse oximetry on skin models with melanin 2.55%–30.5% and SaO2 70%–100%. Ideal monochromatic emission gave the lowest SpO2 error (RMSE 1.32) versus realistic LED spectral profiles (RMSE 2.10); infrared wavelength tolerances added 1.1 ± 0.3 to SpO2 RMSE. Error moved from underestimation (−1.8 ± 0.1%) at 2.55% melanin to overestimation (+3.9 ± 1.2%) at 30.5% for SaO2 70% with LED profiles.
- Form factor: other
Abstract
We investigate the effects of skin pigmentation and light source characteristics on the performance of reflective Pulse oximetry (PO) devices used in healthcare and well-being applications. We use Monte Carlo (MC) simulations to compare ideal monochromatic and realistic LED spectral emission profiles and tolerance-related wavelength shifts. The simulation covers photon transport in skin models with melanin concentrations (2.55% to 30.5%) and arterial oxygen saturations SaO 2 (70% to 100%.) Accuracy was assessed by SpO 2 error, root-mean-square error RMSE ( A rms), and percentile tail-errors (P90, P95, and P99).
Monochromatic spectral emission yielded the lowest SpO 2 error (RMSE = 1.32), while LED spectral emission profiles increased errors (RMSE = 2.10). Infrared wavelength tolerances increased SpO 2 RMSE by 1.1 ± 0.3. SpO 2 error increased with melanin concentration, from underestimation (−1.8 ± 0.1%) at 2.55% melanin concentration to overestimation (+3.9 ± 1.2%) at 30.5% for low SaO 2 (70%) and LED spectral emission profiles. At 30.5% melanin concentration, P95 and P99 exceeded FDA and DIN EN ISO 80601-2-61 thresholds, in particular at low SaO 2 (70%). Clipping SpO 2 estimates at 100% resulted in an apparent RMSE decrease of up to 3%, reflecting error masking rather than real error reduction.
In conclusion, LED spectral emission profiles and wavelength tolerances can amplify melanin-related bias in SpO 2 estimates. Monochromatic emission and tighter wavelength control can reduce SpO 2 error and should be considered in device design and regulation. Regulatory standards should discourage clipping SpO 2 estimates at 100% and mandate additional metrics as RMSE fails to reflect clinically critical percentile error thresholds, i.e. P95 and P99.
Verbatim from the publisher's DOI record (opens in a new tab) · Publisher licence: http://creativecommons.org/licenses/by/4.0/
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Tasks & signals
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How it works
- Wavelengths
- red, IR
Cite this paper
Reiser, M., Breidenassel, A., & Amft, O. (2026). Spectral emission profile and wavelength tolerances affect pulse oximeter performance. bioRxiv preprint. https://doi.org/10.64898/2026.04.20.719559
Reiser, M., A. Breidenassel, and O. Amft. 2026. "Spectral emission profile and wavelength tolerances affect pulse oximeter performance." bioRxiv preprint. https://doi.org/10.64898/2026.04.20.719559.
Reiser, M., Breidenassel, A. and Amft, O. (2026) 'Spectral emission profile and wavelength tolerances affect pulse oximeter performance', bioRxiv preprint. doi: 10.64898/2026.04.20.719559.
Reiser, M., et al. "Spectral emission profile and wavelength tolerances affect pulse oximeter performance." bioRxiv preprint, 2026. https://doi.org/10.64898/2026.04.20.719559.
M. Reiser, A. Breidenassel, and O. Amft, "Spectral emission profile and wavelength tolerances affect pulse oximeter performance," bioRxiv preprint, 2026, doi: 10.64898/2026.04.20.719559.
@misc{reiser2026spectral,
title = {{Spectral emission profile and wavelength tolerances affect pulse oximeter performance}},
author = {Reiser, M. and Breidenassel, A. and Amft, O.},
year = {2026},
howpublished = {bioRxiv preprint},
doi = {10.64898/2026.04.20.719559}
}Added to the ChatPPG research hub
