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Paperdoi:10.3389/fphys.2023.1208010

Non-invasive monitoring of intracranial pressure changes: healthy volunteers study

Venue listed2023Added Nov 5, 2026

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Authors: Maria Roldan, George R. E. Bradley, Elisa Mejía-Mejía, Tomas Y. Abay, Panayiotis A. Kyriacou

Frontiers in Physiology

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CC BY 4.0

TL;DR

Objective: This research aims to evaluate the possible association between pulsatile near infrared spectroscopic waveform features and induced changes in intracranial pressure in healthy volunteers. Methods: An optical intracranial pressure sensor was attached to the forehead of 16 healthy volunteers. Pulsatile near infrared spectroscopic signals were acquired from the forehead during body position changes and Valsalva manoeuvers.

  • Published in Frontiers in Physiology (2023).

Abstract

Objective: This research aims to evaluate the possible association between pulsatile near infrared spectroscopic waveform features and induced changes in intracranial pressure in healthy volunteers.

Methods: An optical intracranial pressure sensor was attached to the forehead of 16 healthy volunteers. Pulsatile near infrared spectroscopic signals were acquired from the forehead during body position changes and Valsalva manoeuvers. Features were extracted from the pulsatile signals and analyses were carried out to investigate the presence of statistical differences in the features when intracranial pressure changes were induced. Classification models were developed utilizing the features extracted from the pulsatile near-infrared spectroscopic signals to classify between different body positions and Valsalva manoeuvre.

Results: The presence of significant differences in the majority of the analyzed features (p 0.05) indicates the technique’s ability to distinguish between variations in intracranial pressure. Furthermore, the disparities observed in the optical signal features captured by the proximal and distal photodetectors support the hypothesis that alterations in back-scattered light directly correspond to brain-related changes. Further research is required to subtract distal and proximal signals and construct predictive models employing a gold standard measurement for non-invasive, continuous monitoring of intracranial pressure.

Conclusion: The study investigated the use of pulsatile near infrared spectroscopic signals to detect changes in intracranial pressure in healthy volunteers. The results revealed significant differences in the features extracted from these signals, demonstrating a correlation with ICP changes induced by positional changes and Valsalva manoeuvre. Classification models were capable of identifying changes in ICP using features from optical signals from the brain, with a sensitivity ranging from 63.07% to 80% and specificity ranging from 60.23% to 70% respectively. These findings underscored the potential of these features to effectively identify alterations in ICP.

Significance: The study’s results demonstrate the feasibility of using features extracted from optical signals from the brain to detect changes in ICP induced by positional changes and Valsalva manoeuvre in healthy volunteers. This represents a first step towards the non-invasive monitoring of intracranial pressure.

Verbatim from the publisher's DOI record (opens in a new tab) · Publisher licence: https://creativecommons.org/licenses/by/4.0/

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Keywords

Kyriacou BibliographyBrain Monitoring Icp

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Roldan, M., Bradley, G. R. E., Mejía-Mejía, E., Abay, T. Y., & Kyriacou, P. A. (2023). Non-invasive monitoring of intracranial pressure changes: healthy volunteers study. Frontiers in Physiology. https://doi.org/10.3389/fphys.2023.1208010
Roldan, Maria, George R. E. Bradley, Elisa Mejía-Mejía, Tomas Y. Abay, and Panayiotis A. Kyriacou. 2023. "Non-invasive monitoring of intracranial pressure changes: healthy volunteers study." Frontiers in Physiology. https://doi.org/10.3389/fphys.2023.1208010.
Roldan, M., Bradley, G. R. E., Mejía-Mejía, E., Abay, T. Y. and Kyriacou, P. A. (2023) 'Non-invasive monitoring of intracranial pressure changes: healthy volunteers study', Frontiers in Physiology. doi: 10.3389/fphys.2023.1208010.
Roldan, Maria, et al. "Non-invasive monitoring of intracranial pressure changes: healthy volunteers study." Frontiers in Physiology, 2023. https://doi.org/10.3389/fphys.2023.1208010.
M. Roldan, G. R. E. Bradley, E. Mejía-Mejía, T. Y. Abay, and P. A. Kyriacou, "Non-invasive monitoring of intracranial pressure changes: healthy volunteers study," Frontiers in Physiology, 2023, doi: 10.3389/fphys.2023.1208010.
@article{roldan2023noninvasive,
  title         = {{Non-invasive monitoring of intracranial pressure changes: healthy volunteers study}},
  author        = {Roldan, Maria and Bradley, George R. E. and Mejía-Mejía, Elisa and Abay, Tomas Y. and Kyriacou, Panayiotis A.},
  year          = {2023},
  journal       = {Frontiers in Physiology},
  doi           = {10.3389/fphys.2023.1208010}
}

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