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First page or project page of “Muscle Sympathetic Nerve Activity Is Related to a Surrogate Marker of Endothelial Function in Healthy Individuals” (opens in a new tab)

Paperdoi:10.1371/journal.pone.0009257

Muscle Sympathetic Nerve Activity Is Related to a Surrogate Marker of Endothelial Function in Healthy Individuals

Venue listed2010Added Oct 30, 2026

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Authors: Yrsa Bergmann Sverrisdóttir, Linda Marie Jansson, Ulrika Hägg, Li-Ming Gan (University of Gothenburg)

PLoS One 5(2):e9257

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First page or project page of “Muscle Sympathetic Nerve Activity Is Related to a Surrogate Marker of Endothelial Function in Healthy Individuals” (opens in a new tab)

Yrsa Bergmann Sverrisdóttir et al., "Muscle Sympathetic Nerve Activity Is Related to a Surrogate Marker of Endothelial Function in Healthy Individuals", doi:10.1371/journal.pone.0009257, CC BY 4.0

TL;DR

Ten healthy adults had resting muscle sympathetic nerve activity recorded by microneurography and endothelial function measured as the reactive hyperaemia peripheral arterial tone (RH-PAT) index using a pneumatic finger plethysmograph. Higher sympathetic burst frequency was strongly associated with a lower RH-PAT index (r = −0.8, p = 0.005), and both related to physical activity level and platelet count.

  • Form factor: finger

Abstract

BackgroundEvidence from animal studies indicates the importance of an interaction between the sympathetic nervous system and the endothelium for cardiovascular regulation. However the interaction between these two systems remains largely unexplored in humans. The aim of this study was to investigate whether directly recorded sympathetic vasoconstrictor outflow is related to a surrogate marker of endothelial function in healthy individuals.Methods and resultsIn 10 healthy normotensive subjects (3 f/7 m), (age 37+/-11 yrs), (BMI 24+/-3 kg/m(2)) direct recordings of sympathetic action potentials to the muscle vascular bed (MSNA) were performed and endothelial function estimated with the Reactive Hyperaemia- Peripheral Arterial Tonometry (RH-PAT) technique. Blood samples were taken and time spent on leisure-time physical activities was estimated. In all subjects the rate between resting flow and the maximum flow, the Reactive Hyperemic index (RH-PAT index), was within the normal range (1.9-3.3) and MSNA was as expected for age and gender (13-44 burst/minute). RH-PAT index was inversely related to MSNA (r = -0.8, p = 0.005). RH-PAT index and MSNA were reciprocally related to time (h/week) spent on physical activity (p = 0.005 and p = 0.006 respectively) and platelet concentration (PLT) (p = 0.02 and p = 0.004 respectively).ConclusionsOur results show that sympathetic nerve activity is related to a surrogate marker of endothelial function in healthy normotensive individuals, indicating that sympathetic outflow may be modulated by changes in endothelial function. In this study time spent on physical activity is identified as a predictor of sympathetic nerve activity and endothelial function in a group of healthy individuals. The results are of importance in understanding mechanisms underlying sympathetic activation in conditions associated with endothelial dysfunction and emphasise the importance of a daily exercise routine for maintenance of cardiovascular health.

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Tasks & signals

Signals

MSNAperipheral-arterial-tone

Keywords

Sympathetic ArousalEndopatMicroneurographyEndothelial FunctionNot Optical PPG

How it works

How Method works: Setup → Method → TargetSetup: Signals (MSNA, peripheral-arterial-tone); Form factor (finger). Method: Method.SetupSignals: MSNA, peripheral-arterial-toneSignalsMSNA, peripheral-arterial-toneForm factor: fingerForm factorfingerMethodMethod

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Sverrisdóttir, Y. B., Jansson, L. M., Hägg, U., & Gan, L.-M. (2010). Muscle Sympathetic Nerve Activity Is Related to a Surrogate Marker of Endothelial Function in Healthy Individuals. PLoS One, 5(2), e9257. https://doi.org/10.1371/journal.pone.0009257
Sverrisdóttir, Yrsa Bergmann, Linda Marie Jansson, Ulrika Hägg, and Li-Ming Gan. 2010. "Muscle Sympathetic Nerve Activity Is Related to a Surrogate Marker of Endothelial Function in Healthy Individuals." PLoS One 5 (2): e9257. https://doi.org/10.1371/journal.pone.0009257.
Sverrisdóttir, Y. B., Jansson, L. M., Hägg, U. and Gan, L.-M. (2010) 'Muscle Sympathetic Nerve Activity Is Related to a Surrogate Marker of Endothelial Function in Healthy Individuals', PLoS One, 5(2), p. e9257. doi: 10.1371/journal.pone.0009257.
Sverrisdóttir, Yrsa Bergmann, et al. "Muscle Sympathetic Nerve Activity Is Related to a Surrogate Marker of Endothelial Function in Healthy Individuals." PLoS One, vol. 5, no. 2, 2010, p. e9257. https://doi.org/10.1371/journal.pone.0009257.
Y. B. Sverrisdóttir, L. M. Jansson, U. Hägg, and L.-M. Gan, "Muscle Sympathetic Nerve Activity Is Related to a Surrogate Marker of Endothelial Function in Healthy Individuals," PLoS One, vol. 5, no. 2, p. e9257, 2010, doi: 10.1371/journal.pone.0009257.
@article{sverrisdottir2010muscle,
  title         = {{Muscle Sympathetic Nerve Activity Is Related to a Surrogate Marker of Endothelial Function in Healthy Individuals}},
  author        = {Sverrisdóttir, Yrsa Bergmann and Jansson, Linda Marie and Hägg, Ulrika and Gan, Li-Ming},
  year          = {2010},
  journal       = {PLoS One},
  volume        = {5},
  number        = {2},
  pages         = {e9257},
  doi           = {10.1371/journal.pone.0009257}
}

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