Paperdoi:10.1038/s42003-023-05211-4
Measuring human cerebral blood flow and brain function with fiber-based speckle contrast optical spectroscopy system
Communications Biology 6(1):844, 2023
(opens in a new tab)Byungchan Kim et al., "Measuring human cerebral blood flow and brain function with fiber-based speckle contrast optical spectroscopy system", doi:10.1038/s42003-023-05211-4, CC BY 4.0
TL;DR
A fiber-based speckle contrast optical spectroscopy system using ordinary CMOS cameras measured changes in human cerebral blood flow during brain activation at 33 mm source-detector separation. Pulsing the laser to raise photon flux, plus a careful processing pipeline, gave more than ten times the signal-to-noise ratio of diffuse correlation spectroscopy at a similar cost.
- Form factor: head
Abstract
Cerebral blood flow (CBF) is crucial for brain health. Speckle contrast optical spectroscopy (SCOS) is a technique that has been recently developed to measure CBF, but the use of SCOS to measure human brain function at large source-detector separations with comparable or greater sensitivity to cerebral rather than extracerebral blood flow has not been demonstrated. We describe a fiber-based SCOS system capable of measuring human brain activation induced CBF changes at 33 mm source detector separations using CMOS detectors. The system implements a pulsing strategy to improve the photon flux and uses a data processing pipeline to improve measurement accuracy. We show that SCOS outperforms the current leading optical modality for measuring CBF, i.e. diffuse correlation spectroscopy (DCS), achieving more than 10x SNR improvement at a similar financial cost. Fiber-based SCOS provides an alternative approach to functional neuroimaging for cognitive neuroscience and health science applications.
Verbatim from the publisher's DOI record (opens in a new tab) · Publisher licence: https://creativecommons.org/licenses/by/4.0
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Tasks & signals
Signals
Keywords
How it works
- Wavelengths
- NIR laser (λ not in abstract)
Cite this paper
Kim, B., Zilpelwar, S., Sie, E. J., Marsili, F., Zimmermann, B. B., Boas, D. A., & Cheng, X. (2023). Measuring human cerebral blood flow and brain function with fiber-based speckle contrast optical spectroscopy system. Communications Biology , 2023, 6(1), 844. https://doi.org/10.1038/s42003-023-05211-4
Kim, Byungchan, Sharvari Zilpelwar, Edbert Jarvis Sie, Francesco Marsili, Bernhard B Zimmermann, David A. Boas, and Xiaojun Cheng. 2023. "Measuring human cerebral blood flow and brain function with fiber-based speckle contrast optical spectroscopy system." Communications Biology , 2023 6 (1): 844. https://doi.org/10.1038/s42003-023-05211-4.
Kim, B., Zilpelwar, S., Sie, E. J., Marsili, F., Zimmermann, B. B., Boas, D. A. and Cheng, X. (2023) 'Measuring human cerebral blood flow and brain function with fiber-based speckle contrast optical spectroscopy system', Communications Biology , 2023, 6(1), p. 844. doi: 10.1038/s42003-023-05211-4.
Kim, Byungchan, et al. "Measuring human cerebral blood flow and brain function with fiber-based speckle contrast optical spectroscopy system." Communications Biology , 2023, vol. 6, no. 1, 2023, p. 844. https://doi.org/10.1038/s42003-023-05211-4.
B. Kim et al., "Measuring human cerebral blood flow and brain function with fiber-based speckle contrast optical spectroscopy system," Communications Biology , 2023, vol. 6, no. 1, p. 844, 2023, doi: 10.1038/s42003-023-05211-4.
@article{kim2023measuring,
title = {{Measuring human cerebral blood flow and brain function with fiber-based speckle contrast optical spectroscopy system}},
author = {Kim, Byungchan and Zilpelwar, Sharvari and Sie, Edbert Jarvis and Marsili, Francesco and Zimmermann, Bernhard B. and Boas, David A. and Cheng, Xiaojun},
year = {2023},
journal = {Communications Biology , 2023},
volume = {6},
number = {1},
pages = {844},
doi = {10.1038/s42003-023-05211-4}
}Added to the ChatPPG research hub
