Paperdoi:10.1364/BOE.9.003937
Wearable speckle plethysmography (SPG) for characterizing microvascular flow and resistance
Biomedical Optics Express 9(8):3937, 2018
TL;DR
This paper introduced wearable speckle plethysmography (SPG). A single laser shining through a finger yields two co-registered waveforms: the classic PPG from light intensity (blood volume) and a new SPG from laser speckle dynamics (blood flow). In 16 people the two waveforms were offset in time and had different harmonic content, which the authors relate to microvascular flow and resistance.
- Form factor: finger
Abstract
In this work we introduce a modified form of laser speckle imaging (LSI) referred to as affixed transmission speckle analysis (ATSA) that uses a single coherent light source to probe two physiological signals: one related to pulsatile vascular expansion (classically known as the photoplethysmographic (PPG) waveform) and one related to pulsatile vascular blood flow (named here the speckle plethysmographic (SPG) waveform). The PPG signal is determined by recording intensity fluctuations, and the SPG signal is determined via the LSI dynamic light scattering technique. These two co-registered signals are obtained by transilluminating a single digit (e.g. finger) which produces quasi-periodic waveforms derived from the cardiac cycle. Because PPG and SPG waveforms probe vascular expansion and flow, respectively, in cm-thick tissue, these complementary phenomena are offset in time and have rich dynamic features. We characterize the timing offset and harmonic content of the waveforms in 16 human subjects and demonstrate physiologic relevance for assessing microvascular flow and resistance.
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Tasks & signals
Signals
Keywords
How it works
- Wavelengths
- coherent source (λ not in abstract)
Cite this paper
Ghijsen, M. T., Rice, T. B., Yang, B. Y., White, S. M., & Tromberg, B. J. (2018). Wearable speckle plethysmography (SPG) for characterizing microvascular flow and resistance. Biomedical Optics Express , 2018, 9(8), 3937. https://doi.org/10.1364/BOE.9.003937
Ghijsen, Michael T., Tyler B. Rice, Bruce Y. Yang, Sean M. White, and Bruce J. Tromberg. 2018. "Wearable speckle plethysmography (SPG) for characterizing microvascular flow and resistance." Biomedical Optics Express , 2018 9 (8): 3937. https://doi.org/10.1364/BOE.9.003937.
Ghijsen, M. T., Rice, T. B., Yang, B. Y., White, S. M. and Tromberg, B. J. (2018) 'Wearable speckle plethysmography (SPG) for characterizing microvascular flow and resistance', Biomedical Optics Express , 2018, 9(8), p. 3937. doi: 10.1364/BOE.9.003937.
Ghijsen, Michael T., et al. "Wearable speckle plethysmography (SPG) for characterizing microvascular flow and resistance." Biomedical Optics Express , 2018, vol. 9, no. 8, 2018, p. 3937. https://doi.org/10.1364/BOE.9.003937.
M. T. Ghijsen, T. B. Rice, B. Y. Yang, S. M. White, and B. J. Tromberg, "Wearable speckle plethysmography (SPG) for characterizing microvascular flow and resistance," Biomedical Optics Express , 2018, vol. 9, no. 8, p. 3937, 2018, doi: 10.1364/BOE.9.003937.
@article{ghijsen2018wearable,
title = {{Wearable speckle plethysmography (SPG) for characterizing microvascular flow and resistance}},
author = {Ghijsen, Michael T. and Rice, Tyler B. and Yang, Bruce Y. and White, Sean M. and Tromberg, Bruce J.},
year = {2018},
journal = {Biomedical Optics Express , 2018},
volume = {9},
number = {8},
pages = {3937},
doi = {10.1364/BOE.9.003937}
}Added to the ChatPPG research hub
